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2048 is a popular puzzle game, there are six Retro Ports to choose from that were designed for Retro Consoles, but thanks to RetroArch we can play these homebrew roms. Stop Being Boring When People Ask So What Do You DoSmall talk will never not be awkward, because to get to know someone you have to ask some fraught questions. Some questions should stay off limits, but its almost always fair game to ask So what do you do for a living Still, answering it can be a pain in the ass. Maybe the last thing you want to talk about is your shitty job. Maybe your job is complicated and you cant easily explain it. Maybe, like me, you go into therapy mode and start unloading all your emotional hang ups about your career. To avoid these traps, try Fast Companys tips on engagingly describing what you do Find something relatable Explain your job the way the average person might come into contact with it. You know how cereal box tops have simpler slots that dont rip My company invented those. If youre in a deadly car accident and its the car companys fault, I decide whether to issue a recall. Skip the nitty gritty details Dont list off your rsum or dump all your career worries. This is especially important for freelancers or entrepreneurs, who might feel required to account for all their income streams. The other person doesnt want time sheets, they want a jumping off point for a pleasant conversation. Pick what youre feeling the best about, whether or not it makes any money, and talk about that. Show instead of tell If you can carry around an example of what you do, go for it. But unless youre at a networking event, dont turn this into a pitch. These tips hit home for the Lifehacker team. Writing careers are non linear and involve a lot of aspirations and concessions, so writers often over explain or self deprecate. This can be awkward for the other person, who might feel obligated to prop up your ego or talk you through a personal crisis. In any line of work, speak confidently about what you do. No ones out to get you with this question. But do tailor your answer to your audience. My Lifehacker colleagues choose the title blogger or journalist depending on how much theyre ready to get grilled about the lamestream media. Theres always a way to play your job up or down, without excessive bragging or self flagellation. My favorite answer to What do you do comes from the father of a childhood friend I provide products and services. He would reveal nothing more. It was a lot more memorable than whatever desk job the guy probably had. How to Answer the Question What Do You Do Without Boring Anyone Fast Company. But do tailor your answer to your audience. My Lifehacker colleagues choose the title blogger or journalist depending on how much theyre ready to get. Welp, Vevo Just Got Hacked. Another day, another multinational video service brought to its knees by a group of rogue hackers with a bone to pick. Vevo, the joint venture between Universal Music Group, Sony Music Entertainment, Abu Dhabi Media, Warner Music Group, and Alphabet Inc. Googles parent company, was just hacked. Roughly 3. 1. 2TB worth of internal files have been posted online, and a couple of the documents reviewed by Gizmodo appear sensitive. The Our. Mine hacker squad has claimed responsibility for the breach. The group is well known They hijacked Wiki. Leaks DNS last month shortly after they took over HBOs Twitter account last year, they took over Mark Zuckerbergs Twitter and Pinterest accounts and they hit both Buzz. Feed and Tech. Crunch not long after that. The leaked cache contains a wide variety of office documents, videos, and other promotional materials. Based on a cursory review, a majority of the files seemed pretty mildweekly music charts, pre planned social media content, and various details about the artists under the record companies management. But not all of the material was quite so benign. Vevos UK office will probably want to get this alarm code changed as soon as possible Our. Mine typically hacks people because, well, it can. The groups primary goal is demonstrating to companies that they have weak security. In this case, the hackers managed to compromise an employee account for Okta, the single sign on workplace app. The future is hell when it comes to device compatibility. Aside from updates bricking devices or rendering them obsolete, youll eventually need to buy allnew. Another day, another multinational video service brought to its knees by a group of rogue hackers with a bone to pick. Usually they dont resort to leaking large caches of filesat least to our knowledgebut in this case it sounds like someone may have pissed them off. In a post late Thursday, Our. Mine claimed it leaked Vevos files after reaching out to one of the companys employees and being told to fuck off. But they informed Gizmodo by email If they asked us to remove the files then we will. Of course, Sony one of Vevos joint owners fell victim to a devastating hack in 2. Guardians of Peace dumped a wealth of its confidential data online. US intelligence agencies pinned the breach on North Korea one of the hacking groups demands was that Sony pull The Interview, Seth Rogans comedy about a plot to assassinate Kim Jong Un. According to Business Insider, Vevo locked up nearly 2. Beyonce, Taylor Swift, and Ariana Grande helping generate some 2. They might consider spending some of those earnings on beefing up their security. This couldve been a lot worse. Weve reached out to Vevo, Sony, Warner, Universal, and Google for comment. Well update if we hear anything back. Update 91. 51. 7 1. ET Responding to our inquiry, a Vevo spokesperson told Gizmodo that the company can confirm that Vevo experienced a data breach as a result of a phishing scam via Linkedin. We have addressed the issue and are investigating the extent of exposure. Additional reporting by Bryan Menegus. Word. 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This Dual Band Wireless Adapter has built in adjustable and detachable omni directional antenna which provides best signal strength and performance. Moreover, if you are having tight corners or edges around your house, the antenna can be adjusted in order to avail best signal strength. Index of weblibros.Parent Directory DLVillanosNiles, Douglas Emperador de Ansalon.DLVillanosWilliams, Michael Teri Takhisis.Jack One Piece WikiToda tierra por la que pisa se que queda rida como si hubiese sufrido una sequaJack.Epteto. La Sequa ,Kangai1Recompensa 1.NombrejaponsJack la Sequa ,Kangai no Jakku2 es un representante de los Piratas de las Bestias, capitn del navo Mammoth y una de las tres calamidades que actan como confidentes de Kaido1.Debido a sus acciones, es considerado el antagonista principal del arco de Zou y uno de los antagonistas centrales en la saga de los Cuatro Emperadores.Apariencia Jack es un hombre excesivamente corpulento y de una enorme estatura.Uno de los rasgos ms caractersticos de su apariencia es su mscara de mandbula metlica con apariencia de rejilla, siendo similar a Morgan o a Jean Ango en este aspecto5.Al igual que la gran mayora de los Piratas de las Bestias, Jack tiene un par de cuernos que emergen de dos orificios circulares de su mscara situados a ambos laterales de su cabeza, siendo especialmente similares a los de Kaido, y otros dos ms largos que emergen de su abrigo y que son en realidad dos espadas con forma de guadaa.Sus ojos son anaranjados5 y su frente amplia.Lleva dos pirsins en la oreja derecha.Su cabello es abundante, rubio, y est recogido con un par de trenzas y peinado en forma de flequillo corto quedando una cuantiosa coleta que se esparce por su espalda16.Su mirada es especialmente intimidante y sanguinaria.Al igual que muchos de los Piratas de las Bestias, Jack viste un largo abrigo marrn oscuro de plumas sin mangas y hombreras puntiagudas, dejando su torso al descubierto.Lleva un cinturn blanco y rojo con el Jolly Roger de su tripulacin alrededor del abrigo, unos pantalones naranjas, y unas botas negras.Cuando su mscara metlica fue destruida por el ataque de Zunisha, se revel que posee dientes de tiburn.Galera. Dientes de tiburn de Jack.LotR-Title-1024x576.jpg' alt='Batallas Por La Tierra Media 2 Cracker' title='Batallas Por La Tierra Media 2 Cracker' />Acercamiento de la mscara de Jack.Acercamiento de la caracterstica mirada colrica de Jack.Jack con el traje de aislamiento de gases venenosos.Noticia de la muerte de Jack en el peridico.Silueta parcial de Jack en su primera aparicin.Jack derrotado. Personalidad Jack es una persona irascible y temeraria, habiendo mostrado enfado por la detencin de Donquixote Doflamingo y persiguiendo a su escolta para rescatarlo pese a que esta se compona de destacados marines de la talla de Fujitora, Sengoku y Tsuru5.Su facilidad para entrar en clera es bien conocida por sus hombres.Caesar2. Hablar. Me niego.Parece detestar entablar una conversacin, demostrando una obstinada irracionalidad no muy diferente a la de su superior, Kaido, siendo incapaz de entrar en razn cuando trataron de explicarle que Raizo no se encontraba en Zou aunque Jack bien podra saber de antemano y con seguridad que el ninja s se encontraba all o cuando le propusieron zanjar el asunto conversando con Inuarashi.Continuad apuntando Si logramos que caiga sobre sus rodillas podremos alcanzar la cabeza.Entonces podremos darle el golpe de gracia Si le sacamos los ojos y le cortamos la lengua, est bienSi le sacamos las tripas del cuerpo, est bien.Jack mostrando su brbara personalidad mientras su flota atacaba a Zunisha.Jack muestra su naturaleza colrica.Jack es un hombre cruel hasta el punto de torturar constante y brutalmente a cada uno de sus presos, llegando a cortar sus extremidades en el proceso.Jack se emplea tan a fondo en sus combates, que no se detiene hasta que su enemigo est completamente aniquilado.As pues, es partidario de la utilizacin de mtodos ilcitos en combate, utilizando Koro, un arma de gas venenoso de Caesar en su lucha contra los minks.La razn por la que acudi a este recurso es porque estaba perdiendo la paciencia, no porque fuese perdiendo la batalla1.Segn lo declarado al duque Inuarashi, ama la destruccin.Su sanguinario carcter tambin es mostrado cuando manifiesta su intencin de vaciarle los ojos y cortarle el estmago y la lengua a Zunisha.Asmismo es un hombre violento, sdico, destructivo y siempre dispuesto a conseguir sus objetivos entendiendo y ejerciendo la piratera en su forma ms brbara y agresiva.Segn lo declarado por Wanda, l interrog y tortur a varios miembros de la Tribu Mink7 y a ambos gobernantes de Zou Inuarashi y Nekomamushi, cortndoles la pierna izquierda y el brazo derecho respectivamente6.Posteriormente arras una ciudad en el Ducado de Mokomo provocando un gran derramamiento de sangre9.Su crueldad se extiende hasta llegar a atacar a personas mayores o a nios sin ningn tipo de miramiento.Su mirada fra y sanguinaria le hace ver como un psicpata vicioso.Algunas personas que lo han conocido lo describen como un demente.No parece importarle los ttulos o la fama, llamando la atencin de sus subordinados cuando estos se jactaron de su posicin y elevada recompensa.Sin embargo, l sigue siendo orgulloso, enfadndose cuando ley en el peridico sobre su aparente muerte.A pesar de su actitud tranquila y sosegada, es todava capaz de sentir miedo si se ve en una difcil situacin.Cuando Zunisha balance su tronco hacia l y su flota con el fin de repelerlos, Jack empez a sudar del miedo y a observar cmo la masiva extremidad oscureca el cielo por encima de su flota con los ojos repletos de pnico.Relaciones Tripulacin.Jack junto a sus subordinados.Como una de los tres calamidades de los Piratas de las Bestias, Jack tiene autoridad sobre los gifters y los pleasures, quienes son increblemente leales a l.Jack no guarda ningn respeto por sus subordinados en ocasiones se le ha visto molesto con ellos, como cuando se jactaron de su recompensa y posicin frente a los minks.No parece importarle la vida de los suyos, ordenndoles atacar a los poderosos minks cuando el conflicto podra haberse solucionado pacficamente.A pesar de esto, sus subordinados parecen amar el combate y no ponen pegas a las rdenes de su lder.Uno de sus subordinados lleg a manifestar miedo ante la reaccin de Jack por la derrota de Caesar Clown, lo que sugiere que la relacin que mantiene con los suyos es una relacin basada equitativamente en el respeto y el temor a su rabia.Cuando Jack decidi atacar la escolta marine de Doflamingo, sus subordinados le aconsejaron dar marcha atrs, pero Jack, molesto, ignor sus peticiones de forma intimidante.Jack tortura a Sheepshead tras fallar su misin.La actitud de Jack es implacable cuando uno de los suyos falla o no efecta bien sus rdenes, llegando a torturar y apresar al cabecilla de los gifters Sheepshead por reportar errneamente que Raizo no se encontraba en Zou.Por esta razn, Ginrummy no le revel la verdadera razn por la cual se marcharon de Zou la llegada de los Piratas de Sombrero de Paja.Kaido. Jack es una de las tres manos derecha de Kaido, lo que implica que tiene gran confianza en l y en su poder1.A pesar de esto, al escuchar sobre la incapacidad de Jack para rescatar a Doflamingo, Kaido pareca ms preocupado por la prdida de su suministro de SAD que por la prdida de su subordinado.Aliados Donquixote Doflamingo A travs de Kaido, Jack se ali con Donquixote Doflamingo, y estaba dispuesto a rescatarle del convoy de la Marine, a pesar de los poderosos marines que lo custodiaban.Fue la derrota y captura de Doflamingo la que hizo a Jack abandonar Zou antes de que pudiese destruir por completo la isla.Enemigos. Tribu mink.En busca de Raizo, Jack tortur e interrog a varios minks7 y dej en ruinas el Ducado de Mokomo9.Como tal, es odiado y temido por esta tribu. Corel Draw 13 Free Download Full Version Crack . Este odio tambin se extiende a Pekoms, de los Piratas de Big Mom, quien se llen de ira al escuchar sobre el saqueo de Jack a su pas.Raizo. Debido a la conexin de Raizo con la familia Kozuki y el objetivo de su superior, Kaido, de obtener el secreto que Kozuki Oden posea sobre Raftel, Jack realiz un gran esfuerzo para encontrar al ninja, reduciendo un pas a escombros en el proceso.Zunisha. Durante su segundo ataque contra Zou, Jack decidi eliminar a la tribu mink y al pas asesinando al gigantesco elefante que lo sostiene Zunisha.Mientras forzaba al elefante a ponerse de rodillas, pens alternativas sdicas para acabar con l.Finalmente, la determinacin de Zunisha para proteger a los minks le llev a aniquilar la flota de Jack con su gran trompa, bajo rdenes de Momonosuke.Habilidades y poderes.Dracule Mihawk One Piece Wiki.Dracule Mihawk. NombrejaponsNombreromanizado.Jurakyru Mihku. Epteto.Ojos de Halcn ,Taka no Me1Edad.Dracule Mihawk ,Jurakyru Mihku5 es un miembro de los Siete Guerreros del Mar4 y el poseedor actual del ttulo de Mejor Espadachn del Mundo ,Sekai Saiky no Kenshi3.Fue quien entren a Roronoa Zoro durante el salto temporal.Apariencia Mihawk tiene una barba corta y patillas, mide 1.Viste ropas adornadas de negro y rojo, con un colgante en forma de crucifijo, que esconde una pequea daga, dndole la apariencia de un espadachn espaol.Su vestimenta consiste en un sombrero de ala ancha adornado con una gran pluma, y un abrigo largo y negro, abierto, con mangas de color rojo, con dibujos de flores y un collar.Su gran espada tiene una hoja negra curvada, y tambin tiene la forma de un crucifijo, con un guardamanos de oro decorada con bolas rojas que son de color azul y verde en el anime, y un puo envuelto en vendas, con una cuenta particularmente grande en su extremidad.Adems, viste pantalones blancos color morado en el anime sostenidos por un cinturn decorado y metidos dentro de botas grandes en comparacin con el tamao de su pierna.Durante su estancia en el castillo de la Isla Kuraigana, usa pantalones diferentes y una camisa blanca abierta con un cuello con volantes.Cuando se encontr afuera con Zoro, tena una capa oscura sobre los hombros.Su apodo proviene de su extrao color de ojos, que se asemejan a los ojos de un halcn.Hace 2. 4 aos, no tena barba y su pelo era ms corto, pero ya tena patillas.Ya tena su colgante de crucifijo, y usaba lo que pareca ser una chaqueta con estampado de flores.Aunque no es visto directamente, se ve que no tena posesin de la Kokuto Yoru en ese momento.Galera. Dracule Mihawk de nio.Mihawk sin su sombrero.Los ojos de Mihawk, iguales a los de un halcn.Dracule Mihawk en Marineford.Vestimenta casual de Dracule Mihawk.Mihawk como mujer.Dracule Mihawk en el opening 1.Videojuegos. Personalidad Dracule Mihawk es posiblemente uno de los personajes ms serios en One Piece, muy poco le sorprende y rara vez sonre.Tom la noticia de la condicin de Luffy como hijo de Dragon con mucha calma, en contraste con la sorpresa de los otros.A diferencia de la mayor parte de los espadachines de la serie, parece tener los pies en la tierra.Si bien no se sorprende con cada nuevo espadachn en los peridicos, sabe reconocer el talento.De hecho, l desea ver a Roronoa Zoro superarlo despus de haber visto su increble determinacin en batalla.Muestra un sentido de honor que a otros Guerreros del Mar le falta, con la excepcin de Bartholomew Kuma antes de su modificacin final en PX 0 y Jinbe.Mihawk es selectivo cuando se trata de cumplir con sus deberes como Guerrero del Mar, como lo demuestra su historia de escasa asistencia a citaciones de los Siete Guerreros del Mar, as como su decisin de cazar y hostigar a unos piratas frente a otros.Zeff especul que la razn de que Mihawk atac a Don Krieg y sus hombres podra haber sido simplemente porque perturbaron su siesta1.Mihawk admiti que la nica razn por la que los sigui todo el camino de regreso al East Blue desde el Grand Line fue para matar el tiempo.Suele mostrar cierta curiosidad por la gente que decide atacar.Trat de atacar a Barbablanca slo para ver la distancia que los separaba a ambos, y atac a Luffy slo para ver si el destino estara del lado de Luffy o no, defendindolo de su espada.Como resultado, Mihawk es muy analtico acerca de las habilidades de otros, y puede reconocer las fortalezas que otros no pueden, como cuando comprendi que el carisma natural de Luffy y la rpida acumulacin de compaeros es su atributo ms peligroso.Tambin parece tener un sentido de hospitalidad, habiendo tolerado a Perona y la presencia de Zoro a su regreso a la Isla Kuraigana despus de la Guerra de Marineford, incluso fue tan lejos como para transmitirle a Zoro los hechos ocurridos en relacin con su capitn, Monkey D.Luffy, as como ofrecindole un barco para ayudar al espadachn Sombrero de Paja a salir de la isla.Al igual que muchos personajes de One Piece, Mihawk tiene su propia y nica risa aunque en su caso, tiene dos whahahaha y kukukuku.Esto rara vez se muestra, ya que casi nunca se re.Una de las razones que le hizo hacerse cada vez ms fuerte es que le gustan los retos, es por eso que no le gusta perder el tiempo peleando con dbiles.Relaciones Mihawk y Shanks.En el pasado, Mihawk fue rival de uno de los piratas ms poderosos en One Piece, Shanks El Pelirrojo cosa que habla mucho de su poder, pero cesaron su rivalidad luego de que Mihawk perdi el inters en pelear con alguien que slo tena un brazo.Parece que saben cmo localizarse si tienen asuntos por tratar como cuando Mihawk le avis del ascenso de Luffy a la piratera.Shanks suelen llevarse bien, no obstante sus personalidades son muy diferentes.Shanks fue capaz de hacer que Mihawk se una a la fiesta para celebrar el avance de Luffy.Mihawk observ que Shanks ya estaba borracho al empezar la fiesta, no obstante bebi junto con l y su tripulacin.Perdname Shanks pero no detendr mi poder, oh Dracule Mihawk a punto de atacar a Luffy en Marineford.Habiendo perdido un rival en Shanks, ahora tiene una rivalidad con Zoro y est listo para esperar a que ste se vuelva mucho ms fuerte y as poder pelear de nuevo.Zoro y empez a divertirle el hecho de que obtuviera su primera recompensa y de que su tripulacin haya derrotado a Crocodile.Mihawk tambin se hizo un peligroso enemigo de Don Krieg, cuando este quiso conquistar el Grand Line.De todas maneras, este asunto se resolvi por s mismo luego de que Mihawk destruyera su flota y de que Luffy derrotara a Krieg.A pesar de formar parte de los siete piratas al servicio del rey, y por tanto, ser odiado tanto por piratas como por marines, se ha ganado el respeto de varios personajes debido a su actitud en batalla, incluyendo entre estos a Zoro, que fue capaz de pedirle que le ensease a mejorar con la espada.Un claro ejemplo de alguien que quera la cabeza de Mihawk, fue Don Krieg, que perdi su flota de 5.Grand Line por tener la mala suerte de coincidir con Mihawk, as como tambin muchos otros piratas y dems personajes que han sido derrotados por l, como se pudo ver tambin en Marineford.Habilidades y Poderes La increble vista de Mihawk, sigue fcilmente el Gear Second de Luffy.Mihawk es un personaje bastante poderoso.Guerreros del Mar, uno de los 3 Grandes Poderes del mundo.Dracule Mihawk es el espadachn ms fuerte del mundo un monstruo superior a los monstruos, como un personaje lo llama.Su poder fue en su da igual al de Shanks, como lo demuestra por el hecho de que ambos han luchado en igualdad de condiciones ms de una vez.Debido a su estatus y poder, derrotarlo es el objetivo final de Roronoa Zoro.De hecho, la fuerza de Mihawk es tan grande que Don Krieg lo acus de tener el poder de una Fruta del Diablo, sin embargo, en los databooks, sus capacidades parecen ser simplemente pura habilidad y poder.Mihawk tambin parece tener fuerza sobrehumana, ya que fue capaz de derrotar a Zoro, un espadachn formidable, con gran maestra y enorme fuerza, incluso lanzndole poderosos ataques en conjunto y destruirlos con espadazos de gran alcance, con slo una Kogatana, y manejndolo con una sola mano.El poder de la Espada Negra.Como corresponde a su epteto, tiene una vista excepcional, pudo seguir fcilmente los movimientos a alta velocidad del Gear Second de Luffy, y atacndolo con extrema precisin, liberando un corte de largo alcance hacia l mientras iba alrededor de la otra gente.Mientras Dracule Mihawk es, en efecto muy potente, debido a la versatilidad de los poderes de las Frutas del Diablo, estn aquellos que no puedan ser daados en absoluto por sus ataques, como Jozu y Buggy.Mihawk viaja por el mundo en una balsa con forma de fretro con dos velas de cera con flamas verdes, una pequea silla negra y un pequeo mstil con vela tambin negra.El hecho de que puede viajar a travs de los bravos mares del Grand Line en una barcaza tan pequea es otro testamento a sus increbles habilidades.Su primera demostracin de poder fue cuando destruy l solo las 5.Krieg, dejando slo su nave principal seriamente daada. Effects Of Diabetes Mellitus On Wound Healing An Update On InformationEffects Of Diabetes Mellitus On Wound Healing An Update On The NatureDiabetes mellitus DM, commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period. Treatment Diabetes The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. TREATMENT DIABETES The REAL cause of Diabetes and. Diabetes Hands Foundation The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. DIABETES HANDS FOUNDATION The REAL cause of. Fracture Healing How Does it Occur. Fracture healing in a broken bone is quite a complex process. To understand the process better we need to have an idea about the anatomy of the bone. Bone is surrounded by a thin membranous layer of tissue called periosteum. See adjoining figure The figure represents a cut section through a bone. Normally the bone is like a cylinder. Imagine cylinder cut into halves along its longitudinal axis and you would get a similar picture. When bone breaks, it bleeds from its torn ends due to disruption of its supplying vessels. Quite naturally the periosteum also is torn as shown in the figure. This periosteum may be completely torn or partially damaged depending upon the force of injury. The collected blood is called fracture hematoma. Due to loss of vascularity or blood supply adjacent portion of broken ends die. Inflammation changes occur in the hematoma over next few hours A reaction by the body which occurs whenever there is an insult to a part or structure. The basic purpose of the inflammation is to contain the damage and facilitate the healing and regeneration. Inflammation is responsible for redness, pain, warmth and tenderness of the wounds and abscesses. This inflammation brings in many cells that would help in regeneration of the broken bone. Periosteum plays a vital role in fracture healing. The periosteum is the primary source of precursor cells which develop into chondroblasts cartilage cells and osteoblasts bone cells that are essential to the healing of bone. As the time progresses, the fibroblasts A kind of cells which produce fibrous tissue in the body get interspersed with small vessels and form a loose mesh like structure uniting the broken ends of the bone and on which the future layers of bone tissue would be added. Over the next few days, the cells of the periosteum replicate and transform. The periosteal cells proximal to the fracture gap develop into chondroblasts and form hyaline cartilage. The periosteal cells distal to the fracture gap develop into osteoblasts and form woven bone a kind of bone which is structurally different from the lamellar bone found in the body. These two new tissues grow until they unite with their counterparts from other pieces of the fracture. This process forms the fracture callus. The callus is the first sign of union visible in x ray and generally appears around two weeks after fracture. Eventually, the fracture gap is bridged by the cartilage and woven bone, restoring some of its original strength. A picture like this is produced. From here on slowly and steadily bone is restructured by a process called remodeling. This was summary of bone healing in simple language. Those who wish to read more detailed process may want to go further. Phases of Fracture Healing How Does a Fracture Heal Fracture healing begins with hemorrhage phase and progresses through repair and remodeling. It must be understood that actual fracture healing is continuous process and the events of different phases may overlap with respect to their occurrence. That means events of preceding phase may continue into next phase and events of subsequent phases may begin in an earlier phase Inflammatory Phase. As a result of fracture, the soft tissue envelope periosteum and surrounding muscles is also torn along with break in the bone, leading to rupture of blood vessels crossing the fracture line. A hematoma is formed within the medullary canal, between the fracture ends, and beneath any elevated periosteum. Due to loss of blood supply, immediate ends of fracture fragments undergo necrosis. Necrotic material leads to an immediate and intense acute inflammatory response which leads to dilation of vessels and exudation of plasma. This brings acute inflammatory cells macrophages, neutrophils and platelets which release several factors such as plasma derived growth factor PDGF, tumor necrosis factor alpha, transforming growth factor beta, IL 1,6, 1. These factors are detected as early as 2. Lack of TNF Alpha has been found to be associated with delay of both ossification e. HIV infectionFibroblasts and mesenchymal cells migrate to fracture site and granulation tissue forms around fracture ends followed by proliferation of osteoblasts and fibroblasts. NSAIDs are known to repress runx 2osterix which is critical for differentiation of osteoblastic cells. Reparative Phase. The repair cells are of mesenchymal origin and are pluripotent cells stem cells probably of common origin of bone, cartilage and collagen. The tissue formed eventually is determined by the microenvironment. High oxygen concentration and mechanical stability favors bone formation whereas low oxygen and instability leads to formation of cartilage. It is notable that blood supply of the extremity is increased as a whole after the fracture but the osteogenic response is limited largely to the zones surrounding the fracture. The repair cells produce the tissue known as callus, which is made up of fibrous tissue, cartilage, and young, immature bone. This quickly envelopes the bone ends and leads to a gradual increase in stability of the fracture fragments. Primary callus forms within two weeks. If the bone ends are not touching, then bridging soft callus forms. Enchondral ossification converts soft callus to hard callus, a type of woven bone. Medullary callus also supplements the bridging soft callus. Amount of callus is dependent on extent of immobilization. As this phase of repair takes place, the bone ends gradually become enveloped in a fusiform mass of callus as noted in picture above. Immobilization of the fragments occurs due to callus and is considered as on of the clinical signs of union. Remodeling Phase. Remodeling about a fracture takes place for a prolonged period of time. In remodeling, osteoclasts resorb the woven bone trabeculae and new struts of bone are laid down that correspond to lines of force. Remodeling is thought to be modulated by electrical signals. When a bone is subjected to stress, electro positivity occurs on the convex surface and electro negativity on the concave, a current produced by a piezoelectric effect. Regions of electropositivity are thought to be associated with osteoclastic activity and regions of electronegativity with osteoblastic activity. The cellular module that controls remodeling is the resorption unit, consisting of osteoclasts, which first resorb bone, followed by osteoblasts, which lay down new haversian systems. Fracture Healing Time Period. Depending on the fracture site, normal healing may take from 3 1. Phalanges 3 weeks. Metacarpals 4 6 weeks. Distal radius 4 6 weeks. Distal Humerus 8 1. Humerus 6 8 weeks. Femoral neck 1. 2 weeks. Femoral shaft 1. Tibia 1. 0 weeks. Types of Fracture Healing. For normal fracture healing to occur a number of requirements must be met Viability of fragments i. Mechanical rest Immobilization by cast or fixation. Absence of infection. Primary bone fracture healing and secondary bone healing are two different types of healing in fractures depending on the rigidity of fixation of the fracture. Fracture stability dictates the type of healing that will occur. When mechanical strain is less than 2, primary bone healing will occur. When the strain is between 2 and 1. Primary Bone Healing. In this kind of fracture healing callus is not formed at all and it occurs with rigid stabilization with or without compression of the bone ends. For example, in a fracture fixed by plating, primary bone fracture healing occurs. It occurs when mechanical strain on the fracture is lt 2. It is also called intramembranous healing and occurs via Haversian remodeling. Rigid stabilization suppresses the formation of a callus in either cancellous or cortical bone. Primary healing per se is rare and most of the fractures heal by secondary healing. This is so because management of most of the fractures allow some degree of movement. Primary bone fracture healing can be divided into gap healing and contact healing. Union occurs in both types. Operated and United Radius and Ulna Fractures Healed By Primary Bone Healing. Rigid stabilization suppresses the formation of a callus in either cancellous or cortical bone. Because most fractures are managed in a way that results in some degree of motion, primary healing per se is rare. Primary bone fracture healing can be divided into gap healing and contact healing. Union occurs in both types. You have not yet voted on this site If you have already visited the site, please help us classify the good from the bad by voting on this site. Download Update. Star Update. Star. Download the. free trial version below to get started. Double click the downloaded file. Update. Star is compatible with Windows platforms. Update. Star has been tested to meet all of the technical requirements to be compatible with. Windows 1. 0, 8. 1, Windows 8, Windows 7, Windows Vista, Windows Server 2. 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